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Overview
Research in the Section of Structural Biology on structural
and biochemical studies of proteins and complexes of importance
in the aetiology and treatment of cancer. In pursuit of this
the Section has established expertise and state-of-the-art
facilities for techniques ranging from molecular biology and
recombinant expression, through protein production and crystallisation,
to X-ray crystallography and molecular modelling, and electron
microscopy.
We apply these techniques to a range of systems of importance
in the prevention, diagnosis and treatment of cancer. Particular
areas of research interest include:
- DNA Damage Recognition, Signalling and Repair
- Signal transduction processes
- Mechanisms and consequences of protein phosphorylation
and protein ubiquitination
- Transcriptional Regulation
- Chaperone Mediated Protein Activation
- Cell Cycle Control
Recent progress in these areas is reported in our list of
highlights of 2002.
The Section receives funding from a wide-range of research
sponsors, including the BBSRC, MRC, Wellcome Trust, EU, Cancer
Research UK and Human Frontiers, and contains the Cancer Research
UK DNA Repair Enzymes Group. Access to synchrotron radiation
sources is available by rolling programmes at SRS Daresbury
and ESRF Grenoble.
The work of the Section is highly multidisciplinary and involves
numerous collaborations with groups within the Institute and
world-wide.
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