Growth Regulation and Angiogenesis Team
Dr Margaret Ashcroft
Like all normal tissues
in the body, cancer cells within a tumour mass need oxygen and
nutrients to grow and expand. A growing tumour mass expands beyond
the microscopic level by developing its own blood supply by stimulating
the growth and invasion of surrounding blood vessels into the
growing tumour mass. This process is known as angiogenesis. Hypoxia
inducible factor-1 (HIF-1) is central to this process and links
tumour hypoxia to tumour progression and angiogenesis by upregulating
specific targets, such as vascular endothelial growth factor (VEGF).
The main focus of the Cell Growth Regulation and Angiogenesis
Team is to gain a better understanding of the molecular mechanisms
underlying HIF-1 regulation in normal and tumour cells, as a basis
for the development of new cancer therapies.
Details of our current research
programme are available in the Projects Database.
Identification, Validation & Selection:
of Preclinical Drug & Gene Therapy:
Evaluation of New Treatments: