Transduction and Molecular Pharmacology Team
Professor Paul Workman
This Team has two major
To understand the molecular mechanism of action of drugs that
affect, or are affected by, signal transduction pathways that
regulate proliferation, cell cycle and survival in cancer cells;
To collaborate with other teams in the Centre and elsewhere to
discover and develop innovative new drugs that act on novel molecular
targets, defined by the genomics and molecular pathology of cancer.
The Team is particularly
involved in the development of inhibitors of the Hsp90 molecular
chaperone, PI3 kinase and cyclin-dependent kinases. In addition
we are interested in applying gene expression microarray and RNAi
technology to understand the cellular pharmacology of molecular
therapeutics and existing cancer drugs.
of our current research
programme are available in the Projects Database.
Identification, Validation & Selection:
of Preclinical Drug & Gene Therapy:
Evaluation of New Treatments: