Signal
Transduction and Molecular Pharmacology Team
Team Leader:
Professor Paul Workman
This Team has two major
complementary roles:
•
To understand the molecular mechanism of action of drugs that
affect, or are affected by, signal transduction pathways that
regulate proliferation, cell cycle and survival in cancer cells;
•
To collaborate with other teams in the Centre and elsewhere to
discover and develop innovative new drugs that act on novel molecular
targets, defined by the genomics and molecular pathology of cancer.
The Team is particularly
involved in the development of inhibitors of the Hsp90 molecular
chaperone, PI3 kinase and cyclin-dependent kinases. In addition
we are interested in applying gene expression microarray and RNAi
technology to understand the cellular pharmacology of molecular
therapeutics and existing cancer drugs.
Details
of our current research
programme are available in the Projects Database.
|
 |
Staff
Contacts
Publications
Jobs
Centre
Structure
Target
Identification, Validation & Selection:
Development
of Preclinical Drug & Gene Therapy:
Clinical
Evaluation of New Treatments:
Last Modified
9/5/05
|