Testicular Cancer Genetics Team
Team Leader:
Professor Michael Stratton
Location: Brookes Lawley Building, Sutton
Section:
Section of Cancer Genetics
Brookes Lawley Building, Sutton
Project Leader: Dr Elizabeth Rapley
|
Cooking recipes, secrets, methods and techniques - Cooking secrets is a free online cooking resource that aims to help cooks finding all recipes they need. Cooking recipes that taste great. |
|
Testicular Germ Cell Tumour (TGCT) is the most common cancer in males aged 15–45 years. In approximately 2% of cases another family member is also affected with testicular cancer, usually the brother or father of a patient. The relative risk to a brother of an affected case is 8–10 fold that of the population risk. This risk is considerably higher than for most other cancer types which rarely exceed 4 and suggests that susceptibility genes are important in this disease. Most of the cancer susceptibility genes isolated to date, such as BRCA1 and BRCA2 in breast cancer, confer a high risk of disease when they are inherited and but are rare variants and contribute to only a small fraction of the cancer susceptibility.
Our research shows that genes of this type do not account for the susceptibility to TGCT. Our studies would suggest that several loci contribute to TGCT susceptibility and that no single gene explains a large fraction of the familial risk. The testicular cancer genetics team aims to identify the genes involved in TGCT susceptibility and obtain a greater understanding of the biology of this disease.
