Prostate Stem Cell Team
Team Leader:
Dr David Hudson
Location: Male Urological Cancer Research Centre, Sutton
Section:
Section of Molecular Carcinogenesis
The Bob Champion Prostate Stem Cell Laboratory
The aims of the Bob Champion Prostate Stem Cell Team are to identify epithelial stem cells in human prostate cancer and to identify potential therapeutic targets that will allow us to either kill the stem cells directly or to induce them to undergo differentiation.
Stem cells (SC) are a small population of cells that divide very occasionally throughout the life of a tissue or tumour. When they divide they replicate themselves but also produce transit-amplifying (TA) cells that are capable of limited proliferation. Ultimately, however, the TA cells will undergo differentiation to a non-proliferating, secretory phenotype and finally die.
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It is becoming clear that stem cells are present not only in normal tissues but also in cancers where they are responsible for driving growth of the tumour. The slow proliferation rate and expression of drug resistance genes means that stem cells may be able to evade some traditional cytotoxic therapies. This implies that current therapies that target differentiated cells do not achieve cure because they are not cytotoxic to cancer stem cells (CSC). We believe that cancer treatments could be dramatically improved if we target stem cells. Therefore targeting these treatments directly to the stem cell population may be of significant clinical benefit.
